CAMBRIDGE, Mass., Dec. 6, 2016 /PRNewswire/ -- Boston Biomedical, an industry leader in the development of novel compounds designed to target cancer stemness pathways, featured two posters on data for DSP-7888, a novel investigational cancer peptide vaccine, at the 2016 American Society of Hematology (ASH) Annual Meeting and Exposition, held from December 3 to 6, in San Diego. These include the first clinical data for the compound, from a Phase I/II trial in adult patients with myelodysplastic syndrome (MDS) who progressed on or after first-line azacitidine (AZA) treatment.
DSP-7888 contains the peptides to induce WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes (CTL) and helper T cells, which attack WT1-expressing cancerous cells found in various types of hematologic and solid cancers. In the Phase I portion of the study, DSP-7888 was well tolerated in MDS patients, and CTL induction and delayed type hypersensitivity (DTH) were detected; the data also demonstrated preliminary signs of clinical activity. The Phase II portion of the trial is currently ongoing to evaluate the efficacy and safety in higher-risk MDS patients after AZA failure.
"DSP-7888 is the third compound in our portfolio to move into clinical investigation, signifying our growing pipeline of first-in-class agents for the potential treatment of cancers with a high unmet need," said Chiang J. Li, M.D. FACP, President, CEO and Chief Medical Officer of Boston Biomedical, and the Head of Global Oncology for Sumitomo Dainippon Pharma Group. "We are encouraged by the data at ASH, which show signs of preliminary activity in patients with MDS, and by the preclinical data exploring the potential synergistic effect of DSP-7888 with PD-1 checkpoint inhibition."
Highlights from the two data posters at ASH follow below:
Abstract #4335: Preliminary Results from a Phase 1/2 Study of DSP-7888, a Novel WT1 Peptide-Based Vaccine, in Patients with Myelodysplastic Syndrome (MDS)
Abstract #4715: DSP-7888, a Novel Cocktail Design of WT1 Peptide Vaccine, and its Combinational Immunotherapy with Immune Checkpoint-Blocking Antibody against PD-1
About DSP-7888
DSP-7888 is an investigational cancer peptide vaccine containing the peptides which induce WT1 (Wilms' tumor gene 1)-specific cytotoxic T lymphocytes and helper T cells, which attack WT1-expressing cancerous cells found in various types of hematologic and solid cancers. By adding a helper T cell-inducing peptide, improved efficacy over that observed with a killer peptide alone treatment regimen may be achieved.
DSP-7888 is currently being investigated in three monotherapy studies: a Phase I/II study in myelodysplastic syndrome (NCT02436252), a Phase I/II study in diffuse intrinsic pontine glioma, glioblastoma, or grade III or IV glioma (NCT02750891) and a Phase I study in advanced malignancies (NCT02498665). More information on DSP-7888 and ongoing clinical trials can be found at www.BostonBiomedical.com.
About Boston Biomedical
Boston Biomedical, Inc. (Founder, President, CEO and CMO: Chiang J. Li, M.D. FACP) was founded in November 2006 and is wholly owned by Sumitomo Dainippon Pharma Co., Ltd. Boston Biomedical's mission is to develop the next generation of cancer therapeutics by creating drugs designed to target cancer stemness pathways. Boston Biomedical's innovation in drug discovery has received a number of recognitions and awards in the United States, including the Frost & Sullivan 2010 North American Drug Discovery Technology Innovation of the Year Award, the National Cancer Institute (NCI) cancer stem cell initiative grant award in 2010, and the 2011 Biotech Pioneer Award at the Alexandria Oncology Summit. The company also received the "Company To Watch" award in the 10th Annual Team Massachusetts Economic Impact Awards in 2013. Boston Biomedical is headquartered in Cambridge, Massachusetts, USA.
Additional information about the company and its product pipeline can be found at www.BostonBiomedical.com.
Disclaimer Regarding Forward-Looking Statements
The forward-looking statements in this press release are based on management's assumptions and beliefs in light of information presently available, and involve both known and unknown risks and uncertainties. Any forward looking statements set forth in this press release speak only as of the date of this press release. We do not undertake to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof. Information concerning pharmaceuticals (including compounds under development) contained within this material is not intended as advertising or medical advice.
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SOURCE Boston Biomedical, Inc.