DURHAM, N.C., April 5, 2017 /PRNewswire/ -- Spyryx Biosciences, Inc., a clinical-stage biopharmaceutical company developing innovative therapeutics to address severe lung diseases, recently presented at both the Needham Healthcare Conference in New York and the European Cystic Fibrosis Society Basic Science Conference in Albufeira, Portugal. These presentations provided updates and data on Spyryx's progress in advancing SPX-101, the Company's pipeline therapeutic treatment for cystic fibrosis (CF).
SPX-101 is an inhaled peptide with a novel mechanism for regulating epithelial sodium channel density in the airway. The drug is designed to restore a cellular pathway in the lung that modulates airway hydration and promotes mucociliary clearance, which is dysfunctional in CF. The mechanism of action of SPX-101 is independent of the genetic mutations that cause CF, which makes it a potential therapy for all CF patients.
Needham Healthcare Conference, New York
John Taylor, President and CEO of Spyryx, provided an update to the financial community on the Company's clinical activities, study results and anticipated milestones for SPX-101, including successful Phase 1 results and plans for Phase 1b and Phase 2 clinical trials in CF patients to begin by mid-2017.
European Cystic Fibrosis Society's 14th Basic Science Conference, Albufeira, Portugal
Spyryx's scientific team presented two abstracts at this meeting, which described the mechanism of action and highlight the potential clinical benefit for SPX-101.
The abstracts presented were:
"We believe the results shared in these studies, combined with the absence of dose-limiting adverse effects in our toxicology and clinical testing, provide a strong scientific rationale for a meaningful benefit of SPX-101 in treating all CF patients, regardless of their CFTR mutation," said Alistair Wheeler, MD, Chief Medical Officer of Spyryx. "The protocols for our pending clinical studies in CF patients have completed review by the clinical community and have been well received. We are excited to have the opportunity to investigate the therapeutic potential of SPX-101 in treating CF-related lung disease. It is our desire to deliver a powerful therapy to the patients suffering from this devastating disease."
About Cystic Fibrosis
CF is an autosomal recessive genetic disorder affecting approximately 75,000 individuals worldwide. The disease is caused by mutations in the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CF profoundly affects the lungs and respiratory tract hallmarked by dehydration of the fluid volume on the airway surface, resulting in reduced clearance of mucus, the lung's principle mechanism for maintaining a clean environment. The mucus becomes thick and sticky, progressively accumulating into obstructions that block oxygen exchange and are recurrently colonized by inhaled viruses and bacteria. These pathogens lead to frequent, acute lung infections, chronic inflammation and impaired lung function. The long-term result of the disease, is progressive, permanent tissue damage and scarring (fibrosis) in the lung. No cure for cystic fibrosis is known, although several treatments have been approved to address the underlying cause of the disease in some patients. Despite currently available treatment, the median age of survival for CF patients is approximately 40 years of age.
About Spyryx Biosciences
Spyryx Biosciences is a privately held, clinical-stage biopharmaceutical company developing innovative therapeutics to address severe lung diseases. Spyryx's lead clinical candidate, SPX-101, is a novel treatment for cystic fibrosis that has successfully completed a Phase 1 study in healthy volunteers and is advancing into Phase 2 in CF patients. The product has demonstrated a robust ability to restore mucociliary clearance in animal models of the disease and has the potential to improve lung function in all cystic fibrosis patients independent of their CFTR mutation. The Spyryx leadership team and scientific staff have extensive experience in the development of respiratory medicines and work closely with a broad group of clinical and scientific experts in the pulmonary field. Spyryx is funded by a first tier syndicate of life science investors, including Canaan Partners, 5AM Ventures and Hatteras Venture Partners. Further information regarding Spyryx Biosciences is available at www.spyryxbio.com.
SOURCE Spyryx Biosciences