News Releases

New Data on Ceplene® Cancer Immunotherapy to be Presented at the 2016 AACR Annual Meeting
Overall Survival was Predicted by Re-Distribution of Cytotoxic T-Cell Subsets During Therapy with Ceplene in Patients with Acute Myeloid Leukemia

NEW YORK, March 17, 2016 /PRNewswire/ -- Immune Pharmaceuticals Inc. (NASDAQ: IMNP) announced today that new clinical pharmacology and outcomes data with Ceplene (histamine dihydrochloride) will be presented by Prof. Kristoffer Hellstrand, Dr. Anna Martner and their scientific colleagues from the University of Gothenburg, Sweden and Università di Roma, Italy, at the upcoming American Association of Cancer Research (AACR) annual conference to be held April 16-20 in New Orleans.

Results of a post-marketing clinical study using Ceplene in patients with acute myeloid leukemia (AML) will be presented at the conference. The study showed that immunotherapy with Ceplene and low-dose IL-2 led to a re-distribution of cytotoxic T-cell subsets in blood towards a tumor-killing phenotype. These immunological properties of Ceplene/IL-2 therapy significantly predicted clinical outcomes such as relapse and survival.  The results illustrate the potential for the use of T-cell biomarkers to accurately predict the efficacy of Ceplene/IL-2 in patients with AML, and to focus treatment on those patients most likely to benefit.

Abstract # CT 116: Dynamics of cytotoxic T cell subsets during immunotherapy predicts outcome in acute myeloid leukemia

Presenters: Anna Martner, Ph.D. and  Kristoffer Hellstrand, M.D., Ph.D
Poster session: Phase II, III, and Special Population Clinical Trials 
Session date and time: Tuesday Apr 19, 2016 1:00 PM - 5:00 PM
Location: Convention Center, Halls G-J, Poster Section 13, Poster Board #16

"Ceplene is a first-in-class histamine receptor agonist in cancer immunotherapy and there are no other drugs approved for remission maintenance in AML. These new data significantly expand our knowledge of the immunological activation pathway following Ceplene/IL-2 therapy in patients suffering from AML and will provide a personalized approach for getting the right treatment to the right patients" said Dr. Miri Ben-Ami, President, Immune Pharmaceuticals (Israel) and Immune's EVP, Global Oncology.

About Ceplene®

Ceplene® is a first-in-class immunotherapeutic, opening a new frontier in immune-oncology by exploiting the ability of histamine binding to the H2 receptor in modulating the immune response to cancer. Ceplene® protects the immune system against inactivation and apoptosis induction by leukemic cells enabling IL-2 stimulated T Cells and Natural Killer (NK) cells to eliminate residual leukemia cells and protect patients against relapse. Ceplene® administered in conjunction with low dose IL-2 immunotherapy is approved in Europe for remission maintenance and prevention of relapse in adults with Acute Myeloid Leukemia, an orphan indication with poor survival prognosis and no effective therapy available to patients to prevent them from relapsing after achieving remission.

About Immune Pharmaceuticals:

Immune Pharmaceuticals (NASDAQ: IMNP) applies a personalized approach to treatment and development of novel, highly targeted therapeutics to improve the lives of patients with inflammatory diseases and cancer. Immune's oncology pipeline includes bispecific antibodies, nanotherapeutics, including NanomAbs, and several mid-to-late stage small molecules including Ceplene®, Azixa® and Crolibulin®. Ceplene is approved in over 30 European countries and Israel.  Immune's lead product candidate for the treatment of inflammatory disease, bertilimumab, is in phase II clinical development for moderate-to-severe ulcerative colitis as well as for bullous pemphigoid, an orphan autoimmune dermatological condition. Other indications being considered for development include atopic dermatitis, Crohn's disease, severe asthma and NASH (an inflammatory liver disease). Immune recently expanded its portfolio in immuno-dermatology with topical nano-formulated cyclosporine-A for the treatment of psoriasis and atopic dermatitis. Immune's non-core pipeline includes AmiKet™, a late clinical stage drug candidate for the treatment of neuropathic pain. For more information, visit Immune's website at, the content of which is not a part of this press release.

Forward-Looking Statements

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SOURCE Immune Pharmaceuticals Inc.

For further information: For further information: Danielle Shapira, Manager, Strategic Planning, IMMUNE Pharmaceuticals, Inc., 646.440.9327,